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NEI Translational Research Program for Therapeutics (R61/R33 Clinical Trial Not Allowed)

US · IL National Institutes of Health (NEI – National Eye Institute) grant open #PAR-26-073

Summary

The National Eye Institute (NEI), part of NIH/HHS, is soliciting applications under its Translational Research Program for Therapeutics using the R61/R33 phased award mechanism. This program supports translational research aimed at developing therapeutics for eye diseases and vision disorders, explicitly excluding clinical trials. The R61 phase typically funds milestone-driven feasibility/development work, while the R33 phase supports more advanced translational development contingent on R61 milestones being met. This opportunity is currently forecasted, with an open date of September 9, 2025.

What they want

Applicants must propose translational research projects focused on the development of therapeutics relevant to the NEI mission (eye diseases and vision disorders). Clinical trials are not allowed under this funding opportunity. The R61/R33 mechanism is a phased innovation award: the R61 phase supports early-stage translational/development milestones, and the R33 phase supports continued development upon successful completion of R61 milestones. Research must advance a therapeutic candidate toward clinical readiness without conducting clinical trials.
Technical requirements
  • Research must be translational in nature, advancing therapeutics toward clinical readiness
  • Clinical trials are explicitly NOT allowed under this funding opportunity announcement
  • R61/R33 phased milestone structure must be followed
  • Research must be relevant to NEI mission areas (eye diseases and vision disorders)

How they evaluate

Submission: Grants.gov federal grants portal (PAR-26-073)

Risks & flags

  • Opportunity is currently in 'forecasted' status — full requirements, budget limits, and due dates are not yet published
  • No dollar value or award ceiling disclosed
  • Scope limited to NEI mission areas, which narrows eligible applicants significantly

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

NEI Translational Research Program for The…
$unknown
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