Summary
This project aims to define how early flavivirus exposures influence dengue virus (DENV) immune responses and clinical outcomes in children, establishing benchmarks for immune correlates of protection against dengue illness.
Defining correlates of protection from dengue illness in a long-term cohort study of multigenerational house-holds in Thailand
US · IL
National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID)
grant
awarded
#nih-5R01AI175941-03
What they want
The project will leverage an ongoing long-term multigenerational family cohort study in Kamphaeng Phet, Thailand, established in 2015 with over 3000 individuals. The study will relate maternally-transferred immunity to dengue illness risk in 750 mother-infant dyads (Aim 1), identify antibody phenotypes associated with protection from post-primary DENV infection in DENV-naïve children (Aim 2), and define the effects of non-DENV flavivirus exposures (JEV vaccination, Zika, JEV infection) on subsequent dengue illness risks (Aim 3). These activities are consistent with NIAID’s mission to better understand, treat, and ultimately prevent infectious diseases.
Deliverables
- Important benchmarks for immune correlates of protection
- Identification of immune correlates of durable, multi-serotypic protection against dengue illness
- Critical benchmarks for diagnostics, triage, and DENV vaccines and immuno-therapies
Technical requirements
- Custom multiplex panel for profiling DENV antibodies in saliva
- Advanced modeling techniques to reconstruct immune kinetics and identify subclinical infections
