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Core A: Biospecimen Repository and Pathology

US · IL NIH grant open #nih-5P50CA217694-07

Summary

The Biospecimen Repository and Pathology Core (CF1) provides support for basic and translational research within a SPORE project by collecting, annotating, storing, distributing, and tracking biospecimens, and offering expert histopathological evaluation and related services.

What they want

CF1 will collect, annotate, store, distribute, and track tissue and blood biospecimens from patients enrolled in research protocols. It will provide expert histopathological evaluation of tumor samples from patients, murine, and xenograft models. The Core will assist in selecting appropriate formalin-fixed, paraffin-embedded (FFPE) and snap-frozen tissue for research, enable the creation of tissue microarrays (TMAs), and assist in performing and interpreting immunohistochemical studies and fluorescence in situ hybridization (FISH) assays. It will also provide scanning and digital archiving of TMA images, interpretation and scoring of IHC results, and systematic assessment of tumor response to therapy in human tissues and sarcoma murine models. CF1 will offer a centralized resource for mutational annotation of sarcoma samples and cell lines using the MSK-IMPACT platform and ensure linkage of specimens to the clinical sarcoma database.
Deliverables
  • Collected, annotated, stored, and distributed tissue and blood biospecimens
  • Expert histopathological evaluations of tumor samples
  • Selected FFPE and snap-frozen tissue for research
  • Tissue microarrays (TMAs)
  • Immunohistochemical study results
  • Fluorescence in situ hybridization (FISH) assay results
  • Scanned and digitally archived TMA images
  • Interpreted, scored, and archived IHC results
  • Systematic assessments of tumor response to therapy
  • Mutational annotation of sarcoma samples and cell lines
Technical requirements
  • Expertise in histopathological evaluation
  • Ability to perform immunohistochemical studies
  • Ability to perform fluorescence in situ hybridization (FISH) assays
  • Capability for scanning and digital archiving of TMA images
  • Proficiency in interpreting and scoring IHC results
  • Experience with MSK-IMPACT platform for mutational annotation

Risks & flags

  • This document describes an existing internal core facility (CF1) within a larger NIH-funded SPORE project, not a competitive procurement opportunity. It details services provided by this core to internal investigators, indicating it is a single-source internal service.

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Health Care & Social Assistance
NAICS 621511
US market size
$2.7T
Typical award
$50K – $100M
Typical buyers
VAHHSDoD MHSIHS
Commonly required
Joint CommissionCMS

Sector-level estimate — full code lookup not yet in catalog.

Core A: Biospecimen Repository and Patholo…
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