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Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33 Clinical Trial Required)

US National Institutes of Health (NIH) grant open #PAR-25-181
Response due Oct 15, 2027 · 00:00 UTC

Summary

This NIH funding opportunity (PAR-25-181) supports the development and testing of psychosocial therapeutic and preventive interventions for mental disorders through the R33 clinical trial mechanism. The R33 phase represents the later-stage, larger clinical trial component of a phased research award (typically following an R61 exploratory phase). Applicants must conduct a required clinical trial as part of their research plan. The opportunity is open from November 2024 through October 2027, suggesting multiple submission cycles.

What they want

Applicants must develop and evaluate psychosocial interventions — therapeutic and/or preventive in nature — targeting mental disorders. The R33 mechanism requires a clinical trial to be conducted. Projects are expected to represent the advanced (efficacy/effectiveness) phase of intervention research, building on prior feasibility or pilot work. Research must comply with NIH clinical trial policies, including registration and reporting requirements.
Technical requirements
  • Clinical trial required (R33 mechanism)
  • Must comply with NIH clinical trial policies including registration and reporting
  • Research must address psychosocial therapeutic or preventive interventions for mental disorders
  • R33 phase implies prior completion or concurrent R61 exploratory phase

How they evaluate

Submission: Grants.gov electronic submission portal

Eligibility & certifications

SAM registration (federal grants compliance)NIH clinical trial registration (ClinicalTrials.gov)Institutional assurances (IRB approval, human subjects protections)

Risks & flags

  • No dollar value or award ceiling stated — budget expectations are unclear without reviewing the full FOA
  • Multi-year open window (Nov 2024–Oct 2027) with likely multiple due dates not specified in this synopsis — applicants should check full PAR-25-181 for exact submission dates
  • R33 mechanism presupposes prior R61 work, which may disadvantage applicants without an existing phased award

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Development of Psychosocial Therapeutic an…
Due Oct 15
Onboard ↗