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Environmental influences on Child Health Outcomes (ECHO) Cohort Data and Biospecimen Access (X01 Clinical Trial Not Allowed)

US National Institutes of Health (NIH) grant unknown #grants-gov-PAR-25-437
Response due Mar 01, 2028 · 00:00 UTC

Summary

This federal funding opportunity through Grants.gov provides researchers access to cohort data and biospecimens collected under the NIH Environmental influences on Child Health Outcomes (ECHO) program. Applicants seek to leverage existing ECHO longitudinal cohort data and/or biospecimens to conduct investigator-initiated research on how early environmental exposures affect child health outcomes. Clinical trials are explicitly not allowed under this mechanism. The X01 mechanism is a resource access award, not a traditional contract, and supports secondary analysis of already-collected data and biological samples.

What they want

Investigators submit X01 applications requesting access to ECHO Program cohort data and/or biospecimens for the purpose of conducting research on environmental influences on child health outcomes. The scope includes: (1) identifying specific ECHO cohort datasets and/or biospecimen collections needed; (2) describing the scientific aims and analytic plan that will be executed using those resources; (3) demonstrating appropriate expertise to analyze the requested data/biospecimens; and (4) complying with ECHO data governance, data use agreement requirements, and biospecimen handling protocols. Clinical trials are not permitted under this opportunity.
Technical requirements
  • Access to ECHO cohort data and/or biospecimens
  • Compliance with ECHO data governance and data use agreements
  • Adherence to biospecimen handling and usage protocols
  • Clinical trials not allowed
  • Secondary analysis of existing collected data/biospecimens only

How they evaluate

Submission: Grants.gov federal grants portal (electronic submission)

Eligibility & certifications

Data Use Agreement (DUA) complianceIRB approval (implied for human subjects research)NIH registration and eRA Commons account

Risks & flags

  • Opportunity is restricted to secondary analysis of pre-existing ECHO program data/biospecimens, inherently limiting eligibility to researchers familiar with the ECHO program infrastructure
  • X01 resource-access mechanism is highly specialized and may favor established ECHO consortium investigators or those with prior ECHO affiliations

Market context

inferred from NAICS
R&D in Physical, Engineering, Life Sciences (except Nanotech & Biotech)
NAICS 541715
US market size
$95B
Typical award
$100K – $50M+
Typical buyers
DoDNSFNIHNASADOE
Commonly required
DCAA-compliant accountingITARCMMC L2
Environmental influences on Child Health O…
Due Mar 01
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