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Slow wave sleep as a biomarker of rehabilitation-induced cognitive improvement in Parkinson's disease

US · IL NIH grant awarded #nih-5R01HD100670-06

Summary

This project investigates whether slow wave sleep (SWS) can serve as a biomarker and mediator for exercise-induced cognitive improvements in individuals with Parkinson's disease (PD), using a Sequential Multiple Assignment Randomized Trial (SMART) design.

What they want

The study will conduct a randomized, controlled trial with 120 Parkinson's disease patients. In the first 12-week phase, participants will be randomized to progressive resistance training (PRT) or a delayed-exercise control group. In the second 12-week phase, responders (those with increased SWS) will continue PRT, while non-responders will transition to endurance training (ET). The delayed-exercise group will begin PRT in the second phase. The study aims to determine the effects of exercise on cognition in PD, if SWS changes mediate exercise-induced cognitive improvements, and if glymphatic function predicts these changes.
Deliverables
  • Research findings on the effects of exercise rehabilitation versus delayed-exercise control on cognition in Parkinson's disease patients
  • Determination of whether changes in slow wave sleep (SWS) due to exercise mediate exercise-induced changes in executive function in Parkinson's disease patients
  • Determination of whether glymphatic function predicts exercise-induced changes in cognition
Technical requirements
  • Sequential Multiple Assignment Randomized Trial (SMART) design
  • Randomized, controlled trial with 120 Parkinson's disease patients
  • 12-weeks of progressive resistance training (PRT)
  • 12-weeks of endurance training (ET)
  • Measurement of slow wave sleep (SWS)
  • Assessment of glymphatic function
  • Assessment of cognitive function, including executive function

Market context

inferred from NAICS
R&D in Physical, Engineering, Life Sciences (except Nanotech & Biotech)
NAICS 541715
US market size
$95B
Typical award
$100K – $50M+
Typical buyers
DoDNSFNIHNASADOE
Commonly required
DCAA-compliant accountingITARCMMC L2
Slow wave sleep as a biomarker of rehabili…
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