Summary
This project aims to identify bacterial species involved in laryngeal epithelial wound healing and define the role of laryngeal microbiota in modulating epithelial regeneration using gnotobiotic and naphthalene-induced injury models.
Microbial modulation of mucosal wound healing in the larynx
US · IL
NIH
grant
open
#nih-5R21DC021012-03
What they want
The project will investigate the role of resident microbiota in acute laryngeal epithelial wound healing by measuring inflammatory markers and barrier protection genes in germ-free and gnotobiotic mice. It will also identify wound-associated bacterial species by analyzing longitudinal dynamics of bacterial compositions and assessing their influence on wound healing in gnotobiotic mice with and without antibiotic treatment.
Deliverables
- New facets of understanding for host-microbiome interactions
- Innovative prevention and treatment strategies for laryngeal diseases with mucosal injury
Technical requirements
- Longitudinal study
- Gnotobiotic laryngeal model
- Naphthalene induced epithelial injury model
- Measuring the expression of inflammatory markers and barrier protection associated genes
- Delineating the longitudinal dynamics of bacterial compositions
- Assessment with and without antibiotics treatment
Market context
inferred from NAICSProfessional, Scientific & Technical Services
NAICS 541714
- US market size
- $2.0T
- Typical award
- $25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP
Sector-level estimate — full code lookup not yet in catalog.
