A life course perspective on gut microbiome aging and health in a non-human primate model

Summary

This project aims to identify changes in gut microbiome functional capacities across the life course in a non-human primate model (Amboseli baboons) to understand how social and environmental factors influence microbiome aging and predict health outcomes.

What they want

The project will utilize a prospective, full life course, nonhuman primate model, specifically the Amboseli baboon population in Kenya. It involves expanding an existing dataset of gut microbial taxonomic composition (17,277 fecal samples over 14 years from 501 baboons) for an additional 10 years to include 800 total individuals. The core work includes analyzing microbiome functional capacity in 12,000 samples, identifying drivers and patterns of microbiome functional aging, and determining which microbiome features predict physical/behavioral aging and all-cause mortality. The ultimate goal is to identify targets for interventions to promote healthy aging.

Deliverables

Identification of changes in the microbiome’s functional capacities across the life course
Testing how social and environmental factors affect the nature and pace of microbiome aging
Testing how taxa-function relationships change at different life stages
Learning which microbiome features predict physical/behavioral aging and all-cause mortality
Identification of targets for interventions aimed at building and sustaining healthy aging

Technical requirements

Focus on gut microbiome’s functional capacities, including microbial genes and metabolic pathways (metagenome data)
Prospective, longitudinal population-based research design
Use of nonhuman primate model (Amboseli baboons)
Analysis of 12,000 samples for microbiome functional capacity

Market context

inferred from NAICS

Professional, Scientific & Technical Services

NAICS 541714

US market size: $2.0T
Typical award: $25K – $50M

Typical buyers

All federal civilianDoDStates

Commonly required

8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.