Summary
This project investigates how myelodysplastic syndrome (MDS)-associated spliceosome mutations compromise myeloid cell function and host defense, leading to increased infection risk.
MDS-Associated Spliceosome Mutations Regulate Host Defense
US · IL
NIH
grant
awarded
#nih-5R01AI155749-05
What they want
The project will use ex vivo studies with mouse and human neutrophils and macrophages, in vivo studies in mice expressing mutant spliceosome genes, and analysis of clinical data from patients with MDS. These studies aim to determine the mechanisms underlying host defense defects in MDS patients with spliceosome mutations.
Deliverables
- Determine the mechanisms underlying host defense defects in MDS patients with spliceosome mutations
- Provide important clinical data about patient risk stratification
