Summary
This research project aims to investigate whether excess dietary sugars contribute to glucose intolerance in adults with cystic fibrosis (CF) and to identify the underlying physiological mechanisms.
A Dietary Intervention to Improve Glucose Tolerance in Adults with Cystic Fibrosis
US · IL
NIH
grant
awarded
#nih-5R01DK133523-04
What they want
The study will test the hypothesis that high-added sugar diets exacerbate a decline in first-phase insulin secretion and insulin resistance by enhancing visceral adipose tissue (VAT) and other ectopic fat deposition, and by promoting an imbalance in systemic aminothiol redox. This will be achieved through an eight-week, double-blind feeding study where a typical high-added sugar, high-fat CF diet is replaced with a eucaloric low-added sugar, high-fat diet. The study will assess changes in insulin secretion and sensitivity, VAT and other ectopic fat deposition, and systemic aminothiol redox.
Deliverables
- New pathophysiological insight into the role of diet towards the development of CF-related diabetes (CFRD)
- Data to inform evidence-based design of dietary approaches and other lifestyle or medical interventions for individuals living with CF
Technical requirements
- Rigorous, double-blind feeding study design
- Assessment of insulin secretion and sensitivity using a combined hyperglycemic clamp and glucose-potentiated arginine stimulation test
- Assessment of visceral adipose tissue (VAT) and other ectopic fat deposition by magnetic resonance imaging (MRI)
- Assessment of systemic aminothiol redox
- Gold-standard metabolic testing and imaging
Market context
inferred from NAICSR&D in Physical, Engineering, Life Sciences (except Nanotech & Biotech)
NAICS 541715
- US market size
- $95B
- Typical award
- $100K – $50M+
Typical buyers
DoDNSFNIHNASADOE
Commonly required
DCAA-compliant accountingITARCMMC L2
