Exercise for Memory Rehabilitation in Epilepsy

Summary

This study aims to determine the efficacy of a 6-week supervised exercise program (endurance and resistance training) for memory rehabilitation in adults with idiopathic generalized epilepsy (IGE), investigate its mechanisms of action, and assess the retention of benefits.

What they want

The project will conduct a randomized delayed intervention clinical trial of a 6-week supervised exercise program combining endurance and resistance training in adults with idiopathic generalized epilepsy (IGE). The study will determine the program's efficacy for memory rehabilitation, investigate the putative mechanisms of action for exercise-related memory benefits, and assess if memory benefits and brain changes are retained 6 weeks post-intervention. The hypothesis is that exercise will significantly improve verbal memory function, mediated by changes in resting state functional connectivity of the hippocampus. A causal-steps approach will be used to determine mediation.

Deliverables

Determination of the efficacy of a 6-week supervised exercise program for memory rehabilitation in IGE adults
Investigation of putative mechanisms of action for exercise-related memory benefits
Determination of retention of memory benefits and brain changes 6 weeks post-intervention

Technical requirements

6-week supervised and structured exercise program combining endurance and resistance training
Randomized delayed intervention study design
Clinical trial methodology
Assessment of verbal memory function
Measurement of resting state functional connectivity of the hippocampus
Causal-steps approach for mediation analysis