Summary
This research project investigates the TCF-1-glucocorticoid regulatory circuit that controls IL-23-driven pathogenicity in Th17 cells, aiming to understand mechanisms relevant to multiple sclerosis.
A TCF1:Glucocorticoid regulatory circuit controls IL-23-driven Th17 pathogenicity
US · IL
NIH
grant
open
#nih-5R01AI176341-03
What they want
The project proposes three aims: 1) Define the role of TCF-1 in opposing IL-23-driven Th17 pathogenicity; 2) Determine how glucocorticoid signaling regulates TCF-1 expression, IL23R signaling, and Th17 pathogenicity; and 3) Determine the role of cell-intrinsic steroidogenesis in opposing Th17 pathogenicity. This will involve using novel conditional knock-out mice to mechanistically dissect the regulatory circuit.
