Summary
THE NEIGHBORHOODS STUDY: CONTEXTUAL DISADVANTAGE AND ALZHEIMER?S DISEASE AND RELATED DEMENTIAS (ADRD) - DEMENTIA DUE TO ALZHEIMER’S DISEASE AND RELATED DEMENTIAS (ADRD) DISPROPORTIONATELY IMPACTS RACIAL/ETHNIC MINORITIES AND THE SOCIOECONOMICALLY DISADVANTAGED. DEVELOPMENT OF EFFECTIVE INTERVENTIONS REQUIRE MECHANISTIC UNDERSTANDING OF DISTAL FUNDAMENTAL FORCES, INCLUDING SOCIOECONOMIC CONTEXT (I.E. “NEIGHBORHOOD DISADVANTAGE” OR THE SOCIAL DETERMINANTS OF HEALTH OF A GIVEN AREA), THAT PUT PEOPLE AT “RISK FOR [MORE PROXIMAL] RISKS” SUCH AS INDIVIDUAL-LEVEL INCOME, EDUCATION, HEALTH BEHAVIORS AND COMORBIDITY. PRIOR RESEARCH SUPPORTS THAT CONTEXTUAL DISADVANTAGE IS MODIFIABLE AND INTERACTS WITH BIOLOGICAL PROCESSES TO PRODUCE DISEASE, YET LITTLE IS KNOWN OF ITS IMPACT ON ADRD. TOWARDS THIS, WE CREATED VALIDATED QUANTIFICATIONS OF NEIGHBORHOOD DISADVANTAGE FOR THE FULL US. THIS AREA DEPRIVATION INDEX (ADI) INCORPORATES POVERTY, EDUCATION, HOUSING AND EMPLOYMENT INDICATORS; PREDICTS DISPAR
