Summary
PROJECT ABSTRACT Patients with type 2 diabetes (T2DM) are at increased risk (~50%) relative to non-diabetic individuals of suffering sudden cardiac death (SCD), most often due to fatal ventricular arrhythmias such as torsades de pointes (TdP). However, the underlying molecular mechanisms are unknown. Therefore, there is the critical need to identify and validate novel cellular proarrhythmic mechanisms in T2DM. In that regard, we have identified and validated a proarrhythmic lipid mediator, leukotriene B4 (LTB4), that is elevated in diabetes compared to non-diabetic patients suggesting that ri
