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Genetic Strategies for Neurodevelopmental Research

US · IL NIH grant awarded #nih-5R01MH121447-05

Summary

Develop a nonhuman primate (rhesus monkey) model of Autism Spectrum Disorder (ASD) by genetically modifying the CHD8 gene using CRISPR/Cas9 techniques, and establish infrastructure for generating genetically modified monkeys for translational biomedical research.

What they want

The project aims to develop a nonhuman primate model of ASD through loss-of-function modifications to the CHD8 gene, which is frequently mutated in individuals with ASD and associated with macrocephaly/megalencephaly. The work involves implementing gene editing strategies for nonhuman primates, validating gene editing, efficiently producing embryos for implantation, producing up to ten live rhesus monkeys with Chd8 loss-of-function mutations, determining normal and abnormal trajectories of structural and functional brain development in these monkeys, and carrying out behavioral analyses of the genetically modified offspring. A long-term goal is to establish infrastructure for generating genetically modified monkeys for broader translational biomedical research.
Deliverables
  • Strategies for gene editing of nonhuman primates
  • Validation of gene editing and efficient production of embryos for implantation
  • Up to ten live rhesus monkeys with Chd8 loss of function mutations
  • Determination of normal and abnormal trajectories of structural and functional brain development for rhesus monkeys with Chd8 loss of function mutations
  • Behavioral analyses of genetically modified offspring
Technical requirements
  • CRISPR/Cas9 gene editing techniques
  • Genetic modification of nonhuman primates (rhesus monkeys)
  • Expertise in neurodevelopmental disorders research
  • Expertise in genetic manipulations for animal models
Key personnel
  • Leadership Group

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

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