Summary
Substance misuse, encompassing opioid misuse, non-opioid illicit use, and alcohol misuse, constitutes a heterogeneous set of conditions associated with high mortality and is a primary driver of rehospitalizations. Despite efforts to reduce harm through tertiary prevention strategies centered on fatal events, the substance misuse epidemic has continued to escalate. Recently, we constructed the Substance Misuse Data Commons (SMDC), a first-of-its-kind data platform that captures early warning signs - emergency department visits and hospitalizations - that lie on the path to fatality and that the
