Summary
PROJECT SUMMARY Tissue engineered vascular grafts (TEVGs) are a promising alternative to autologous tissues, yet none have been clinically approved for small-diameter revascularization due to pathological remodeling. Our lab previously showed TEVGs made from decellularized arteries had severe calcification which was associated with vascular smooth muscle cell (VSMC) osteogenic transdifferentiation and oxidative stress. We are now developing TEVGs resistant to calcification using matrix metalloprotease - degradable polyethylene glycol hydrogels (MMP- PEG) to coat the adventitial surface of dec
