Summary
Project Summary The host lipid environment is a well-described barrier to bacterial infection at several sites including the skin, lung, and upper airways. In addition, both bacterial and host lipids serve as signals that promote inflammation. Bacterial lipids activate Toll-like receptors which initiates cytokine production, immune cell recruitment, and induction of oxidative burst to control infection. Several pathogenic bacteria evade these lipid-mediated defenses by secreting lipolytic enzymes (lipases). Bacterial lipases can cause host membrane dissolution, facilitate escape from cellular
