Summary
The instrumental role of systematic gene knockdown studies, using RNA interference (RNAi), in identifying lifespan-extending gene alterations in model organisms like C. elegans is well established. In contrast, systematic gene overexpression remains mostly unexplored, representing a major knowledge gap in our understanding of the genetic basis of longevity and health. This gap exists primarily due to previous technological limitations which restricted studies to a limited selection of candidate genes. The recent advancements in CRISPR technology for C. elegans overcome those hurdles. These inn
