Summary
This project aims to elucidate the genetic and molecular basis of myocardial infarction (MI) in patients with coronary artery disease (CAD), specifically identifying and validating MI-specific genetic risk factors like SLC44A3.
Genetic Predisposition to Myocardial Infarction in Patients with Coronary Artery Disease
US · IL
NIH
grant
awarded
#nih-7R01HL168493-02
What they want
The project involves integrative genetics, bioinformatics, and functional analyses in humans and mouse models. Specific Aim 1 will comprehensively elucidate the genetic landscape of MI in CAD patients through large-scale meta-analyses and whole-exome rare variant analyses with multi-ancestry cohorts, prioritizing candidate causal genes using bioinformatics, fine-mapping, and functional genomics. Specific Aim 2 will experimentally validate Slc44a3 as an MI-specific susceptibility gene using a translational in vivo mouse model of plaque rupture.
Deliverables
- Elucidation of the genetic landscape of MI in patients with CAD
- Prioritization of candidate causal genes for MI among CAD patients
- Experimental validation of Slc44a3 as an MI-specific susceptibility gene in mouse models
Technical requirements
- Large-scale meta-analyses
- Whole-exome rare variant analyses
- Bioinformatics analyses
- Fine-mapping analyses
- Functional genomics analyses
- Translational in vivo mouse model of plaque rupture
