Summary
Project Summary/Abstract The goal of this proposal is to develop a platform created from advanced biomaterials that enable novel investigations into the physiochemical roles of the tumor microenvironment (TME) on the origins of colorectal cancer. Colorectal cancer is a leading cause of cancer deaths in the U.S. and is increasing in incidence. Virtually all of these tumors arise from adenomas or polyps whose progression to cancer is driven by physical and chemical changes within the TME in concert with genetic mutations. Although much is known about the genetics of colon cancer, relatively litt
