Summary
ABSTRACT. Non-tuberculous mycobacteria (NTM) constitute a major threat to global health with over 200,000 annual cases in the United States alone. Mycobacterium avium complex (MAC) infections are the most common cause of NTM pulmonary disease, producing a five-year all-cause mortality rate of 25%. M. avium (Mav) accounts for the majority of MAC with M. intracellulare (Mae) being the next most common pathogen in this group. MAC is usually treated with three drugs; however, the success rate of even multi-drug therapy is unacceptably low at ~60%. Furthermore, drug resistance can develop during t
