Summary
Project description Gut epithelium is the principal site in which neural, immune, microbial and dietary factors interact. These multi-system interactions critically regulate whole-body physiology including metabolism, immunity, and neurodegenerative diseases. Gut epithelium is exposed to a myriad of mechanical forces that are generated by gut peristalsis and food passing. These forces include shear stress, stretch, and compression. Despite growing interest in mechanobiology, mechanisms of gut mechanosensing and its effects on physiology and diseases remain largely unexplored. In this project,
