Summary
This project aims to understand the regulation of stem-like CD8+ T cells and their interactions within the tumor micro-environment to improve the efficacy of immune checkpoint blockade in cancer immunotherapy.
Regulation of stem-like CD8+ T cells and their role in immunotherapy
US · IL
NIH
grant
awarded
#nih-5R01CA187975-10
What they want
The project investigates the role of stem-like CD8+ tumor-infiltrating lymphocytes (TILs) in the response to immune checkpoint blockade (ICB). It will determine the role of TCF-1 and novel candidate regulators in generating proficient anti-tumor T cell responses, and characterize the crosstalk between stem-like CD8+ TILs and the tumor micro-environment (TME), including antigen-presenting cells. The overarching goal is to understand how these factors govern the activation of anti-tumor CD8+ T cell responses and ICB efficacy.
Deliverables
- Determination of the role of TCF-1 in the generation of proficient anti-tumor T cell responses
- Testing of novel candidate regulators of stem- and effector-like CD8+ TILs
- Characterization of the crosstalk between stem-like CD8+ TILs and the TME
Technical requirements
- Expertise in population and single-cell RNA profiling of CD8+ TILs
