Personalized Closed-loop Theta Burst Stimulation for Treatment of Depression

Create a closed-loop TBS-EEG system that integrates spatial precision using individual structural magnetic resonance imaging (MRI) for neuronavigation and temporal precision using real-time electroencephalography (EEG). The system will compensate for inter-individual variability in prefrontal anatomy, focusing on the individual center of the dorsolateral prefrontal cortex (DLPFC). Ongoing EEG will inform the system about prefrontal cortex excitatory/inhibitory states to trigger stimulation pulses at optimal times. Functional precision will be improved by tagging individual prefrontal brain oscillations (theta and gamma) during a validated cognitive test to derive personalized TBS parameters. A double-blinded, placebo-controlled study in healthy humans and a feasibility study in a clinical population will be conducted to assess the long-lasting effects of the personalized TBS-EEG on prefrontal electrophysiology and depressive behavior.