Summary
Project Summary Staphylococcus aureus is a leading cause of nosocomial infection in the United States and is a predominant pathogen in communities. S. aureus survives during infection by subverting immune defenses and adapting to host-imposed nutrient restriction. Yet, we lack a unifying understanding of how these adaptations promote survival in the host. The work outlined in this proposal stems from our longstanding research on an essential cofactor required for metabolic enzyme function, lipoic acid (LA), which is a critical mediator of S. aureus growth and survival during infection. Our pri
