← Back to contracts

HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)

US National Institutes of Health (NIH) grant open #RFA-NS-25-023
Response due Jan 15, 2027 · 00:00 UTC

Summary

This NIH funding opportunity under the HEAL (Helping to End Addiction Long-term) Initiative solicits research applications focused on enabling analgesic discovery. The R61/R33 phased award mechanism supports preclinical and translational studies aimed at advancing non-opioid or improved pain treatment options. Clinical trials are explicitly not allowed under this announcement. The opportunity is open for an extended multi-year window, reflecting a standing/reissued funding opportunity announcement (FOA).

What they want

Applicants must propose studies that enable analgesic discovery in alignment with the NIH HEAL Initiative. The phased R61/R33 mechanism requires an R61 milestone-driven exploratory phase followed by an R33 expanded research phase contingent on meeting R61 milestones. Clinical trials are explicitly excluded. Research is expected to focus on preclinical, mechanistic, or translational science that advances the identification or development of novel analgesic compounds or targets.
Technical requirements
  • Clinical trials are not allowed under this FOA
  • Must use R61/R33 phased award mechanism
  • Research must support analgesic discovery goals aligned with HEAL Initiative objectives

How they evaluate

Submission: Grants.gov electronic submission portal

Risks & flags

  • Extremely long open window (09/2024–01/2027) suggests a standing/reissued FOA with multiple receipt dates — applicants should check NIH Guide for specific submission deadlines
  • No dollar value or award ceiling stated in the source text — budget limits may be embedded in the full FOA

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

HEAL Initiative: Studies to Enable Analges…
Due Jan 15
Onboard ↗