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INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)

US · MD National Institutes of Health (NIH) grant open #RFA-OD-27-004
Response due Jun 15, 2028 · 00:00 UTC

Summary

The NIH INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project is soliciting transformative research proposals focused on Down syndrome under the R01 mechanism. Clinical trials are explicitly not allowed under this funding opportunity. The award aims to advance scientific understanding of Down syndrome and co-occurring conditions across the lifespan. This is a federal grant opportunity listed on Grants.gov under RFA-OD-27-004.

What they want

Technical requirements
  • Clinical trials are NOT allowed under this funding opportunity
  • Must align with INCLUDE Project research priorities for Down syndrome
  • R01 grant mechanism applies

How they evaluate

Submission: Grants.gov electronic submission portal

Risks & flags

  • Extremely long open window (over 2 years: May 2026 – June 2028) may indicate rolling review cycles or phased solicitation — unusual for a single RFA
  • Restriction to 'Clinical Trial Not Allowed' significantly narrows eligible applicant pool to basic/translational researchers only

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

INCLUDE Project: Transformative Research A…
Due Jun 15
Onboard