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NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required)

US · MD · Bethesda National Institutes of Health - National Center for Complementary and Integrative Health (NCCIH) grant open #PAR-25-271
Response due Nov 13, 2026 · 00:00 UTC

Summary

The National Center for Complementary and Integrative Health (NCCIH), a component of the National Institutes of Health (NIH), is soliciting R01 research grant applications for mid-phase clinical trials investigating natural products. This opportunity is specifically designated as requiring a clinical trial, suggesting applicants must propose and conduct a structured human clinical trial examining the efficacy, safety, or mechanisms of a natural product. The funding opportunity is open for an extended window spanning nearly two years, consistent with NIH standing program announcement cycles.

What they want

Applicants must propose and execute a mid-phase clinical trial (typically Phase II) studying natural products under the R01 grant mechanism. The clinical trial is required — not optional — as part of the application. Research must align with NCCIH's mission of investigating complementary and integrative health approaches, specifically focusing on natural products (e.g., botanicals, dietary supplements, probiotics). Work includes trial design, participant recruitment, intervention delivery, data collection, analysis, and reporting of results.
Technical requirements
  • Clinical trial must be mid-phase (Phase II equivalent)
  • R01 grant mechanism required
  • Clinical trial is required — not optional
  • Research must focus on natural products
  • Must comply with NIH human subjects research regulations
  • Must align with NCCIH mission and priorities

How they evaluate

Submission: Grants.gov federal grants portal (PAR-25-271)

Risks & flags

  • No dollar value or award ceiling stated — budget constraints are unclear without reading the full FOA
  • Extended two-year open window is standard for NIH program announcements but may obscure rolling deadline nuances and specific receipt dates
  • Highly specialized scope (mid-phase natural product clinical trials) may limit competitive field to established research institutions with prior NCCIH funding history

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

NCCIH Natural Product Mid Phase Clinical T…
Due Nov 13
Onboard ↗