Summary
SUMMARY Converting the host cell into a supportive niche is essential for intracellular pathogen survival and replication. Orientia tsutsugamushi is a genetically intractable obligate intracellular bacterium that causes scrub typhus, a globally emerging infection with a high fatality rate. Disease progression depends on bacterial-driven modulation of host antimicrobial responses that affords Orientia the ability to replicate to high loads in endothelial cells. The bacterial mechanisms responsible are largely unknown, highlighting a gap in our knowledge of host-pathogen interactions that influe
