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Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)

US · DC National Institutes of Health (NIH) grant open #RFA-NS-26-001
Response due Nov 10, 2026 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is soliciting applications under RFA-NS-26-001 for U01 cooperative agreement awards focused on Amyotrophic Lateral Sclerosis (ALS) expanded access for an intermediate patient population. This is a clinical trial-required funding opportunity, meaning applicants must propose and conduct a clinical trial as part of their research plan. The opportunity is administered through the NIH and published via Grants.gov.

What they want

Applicants must propose and execute a U01 cooperative agreement clinical trial targeting expanded access for an intermediate ALS patient population. The research must be structured as a clinical trial and conform to NIH U01 cooperative agreement requirements. Full programmatic scope details are expected to be contained in the full RFA document (RFA-NS-26-001) available through NIH/Grants.gov.
Technical requirements
  • Must propose and conduct a clinical trial (clinical trial required mechanism)
  • Must comply with NIH U01 cooperative agreement requirements
  • Research must target ALS intermediate patient population expanded access

How they evaluate

Submission: Electronic submission via Grants.gov federal grants portal

Risks & flags

  • Very limited programmatic detail available in synopsis — full scope, budget limits, and eligibility requirements cannot be assessed without the full RFA document
  • Clinical trial requirement (U01) may narrow the eligible applicant pool significantly to organizations with active IND or established clinical infrastructure

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Amyotrophic Lateral Sclerosis (ALS) Interm…
Due Nov 10
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