Summary
This program project grant investigates how gain-of-function mutations in the STAT3 gene predispose individuals to immune dysregulation and aims to discover methods to reverse this defect, focusing on immune tolerance and autoimmunity.
STAT3 variants as a rheostat of immune tolerance
US · IL
NIH
grant
awarded
#nih-5P01AI155393-05
What they want
Three complementary and highly collaborative teams, led by Drs. Megan Cooper, Mark Anderson, and Alex Marson, along with two scientific cores, will conduct research across four major themes: 1) refined analysis of immune cell dysfunction in STAT3 GOF patients, 2) using state-of-the-art animal modeling to interrogate STAT3 GOF mutations in skin inflammation and type 1 diabetes, 3) utilizing CRISPR/Cas9 methods to interrogate STAT3 GOF dysfunction, and 4) modeling methods to genetically repair defective STAT3 in human cells. The long-term objective is to improve understanding of STAT3's role as a rheostat controlling immune tolerance and dysregulation, refining understanding of autoimmunity inflammation and improving treatment and diagnosis methods.
Technical requirements
- State-of-the-art animal modeling approaches
- State-of-the-art CRISPR/Cas9 methods
- Modeling methods to genetically repair defective STAT3 in human cells
Key personnel
- Dr. Megan Cooper (Project Head)
- Dr. Mark Anderson (Project Head)
- Dr. Alex Marson (Project Head)
