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Using Glycomic Signatures to Monitor Disease Progression and Predict Treatment Response in Lupus Nephritis

US · IL NIH grant awarded #nih-1F30DK142473-01A1

Summary

This research proposal aims to identify sensitive and less invasive clinical biomarkers, specifically glycomic signatures in urine, for monitoring lupus nephritis (LN) progression and assessing treatment response, complementing current clinical methods.

What they want

The project involves evaluating the precision of distinct glycomic signatures in identifying lupus nephritis (LN) compared to controls, and ascertaining their efficacy in differentiating between complete responders and non-responders to treatment. Additionally, the research will focus on determining the spatial localization of N-glycans within the kidney and identifying their protein carriers using an independent LN cohort with matched serum, urine, and kidney biopsy samples. The ultimate goal is to deepen the understanding of LN pathophysiology, evaluate the predictive potential of glycomic signatures for disease severity and treatment response, and introduce a less invasive urine-based approach to enhance patient care.
Deliverables
  • Evaluation of precision of distinct glycomic signatures in identifying LN compared to controls (Aim 1A)
  • Ascertainment of efficacy of unique glycomic profiles in enhancing differentiation between complete responders (CR) and non-responders (NR) (Aim 1B)
  • Determination of spatial localization of N-glycans within the kidney (Aim 2A)
  • Identification of protein carriers of N-glycans (Aim 2B)
  • Deeper understanding of LN pathophysiology
  • Evaluation of predictive potential of glycomic signatures for disease severity and treatment response
  • Introduction of a less invasive urine-based approach
Technical requirements
  • Mass spectrometry-based techniques

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Using Glycomic Signatures to Monitor Disea…
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