Pharmacokinetics of Long-Acting Preparations of Antitubercular Drugs in Rodents

The purpose of these Indefinite Delivery/Indefinite Quantity (IDIQ) contracts is to provide the extramural scientific community with research materials and preclinical product development support for candidate products emerging from investigator-initiated research or collaborations. The scope encompasses activities from basic research and initial product discovery to those required for clinical trials and/or product licensure, supporting Investigational New Drug Application (IND), Investigational Device Exemption (IDE), and/or New Drug Application (NDA) filings with the FDA. NIAID Division of AIDS will use these contracts to fill critical development and resource gaps. This specific task order aims to determine the pharmacokinetics (PK) of long-acting preparations for tuberculosis of BTZ-043, TBAJ-876, and Pretomanid in rodents.