Summary
Project Summary/Abstract Asthma is a debilitating lung disease marked by reversible airway obstruction that affects over 5% of the US population and is growing in prevalence. In the majority of cases of asthma, allergic inflammation around the bronchial airways contributes to disease pathogenesis. A key pathway in the initiation of allergic immune responses is elicited by antibodies of the IgE isotype. In allergic individuals, IgE antibodies are produced with specificity for components of harmless environmental substances, termed allergens. However, the mechanisms responsible for the productio
