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Evolution and mechanisms of pathogen avoidance

US · IL NIH grant awarded #nih-1K99GM159248-01

Summary

This K99 research project investigates the evolutionary and mechanistic interplay between innate and learned pathogen avoidance behaviors, using *Caenorhabditis elegans* and *Serratia marcescens* as a model system, to understand their genomic and neural underpinnings.

What they want

The research will examine how hosts reduce pathogen contact through two mechanisms: innate avoidance (without prior experience) and learned avoidance (after encountering a pathogen). The first objective is to identify the role of innate avoidance in the evolution of pathogen defense, utilizing experimental evolution and whole-genome sequencing. The second objective is to determine how innate and learned avoidance are integrated to produce effective responses, by studying behavioral and neuronal responses to diverse pathogen strains. The project aims to support the applicant's transition to research independence in genomics, neuroscience, and behavioral biology.
Technical requirements
  • Use of model nematode host: Caenorhabditis elegans
  • Use of virulent bacterial pathogen: Serratia marcescens
  • Experimental evolution techniques
  • Whole-genome sequencing
  • Study of behavioral and neuronal responses
Key personnel
  • Individual researcher (applicant) transitioning to research independence

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Evolution and mechanisms of pathogen avoid…
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