Summary
PROJECT SUMMARY Aging is a significant risk factor for age-related macular degeneration AMD, a leading cause of blindness among the elderly. Aging and AMD induce progressive changes in Bruch’s membrane but to varying extents. There is increasing evidence that the physical properties of tissues, particularly the extracellular matrix (ECM) can influence tissue homeostasis and function. The ECM plays a critical role in the biomechanical properties of tissue. Deciphering the protein composition of the ECM and how it changes in the context of aging and disease pathology is an important first step t
