Summary
This project aims to understand how protein motion contributes to function by developing new computational methods for processing and interpreting data representing conformational disorder, integrating cryo-electron microscopy (cryo-EM) with advanced X-ray methods.
What they want
The project applies an interdisciplinary approach, leveraging understanding of scattering-based structural methods to develop computational tools for analyzing conformational disorder. Past work includes extracting dynamic information from protein crystals and mapping structural interconversions of allosteric and flexible enzymes. Future work will integrate cryo-EM with advanced X-ray methods to address fundamental questions about protein allostery and catalysis, focusing on capturing correlated motions in allosteric networks, applying mathematical decomposition to conformational heterogeneity, and probing protein motions that control catalysis.
Technical requirements
- cryo-electron microscopy (cryo-EM)
- advanced X-ray methods
