Summary
Support for the Children's Oncology Group (COG) to continue its collaborative research on childhood and adolescent cancer, focusing on improving outcomes and quality of life through clinical-translational studies and novel therapeutic approaches.
What they want
The Children’s Oncology Group (COG) will design and conduct clinical-translational studies for children with cancer, building on an increasing understanding of the molecular basis for pediatric malignancies. This includes studying novel therapeutic approaches such as targeted small molecule drugs, immunotherapies, and cellular therapies, using innovative clinical trial designs suitable for rare diseases. The research portfolio also includes clinical trials focused on improving the quality of life for children with cancer and childhood cancer survivors. The effort involves collection and annotation of biospecimens from all children with cancer, providing a foundation for discovery. The proposal supports the COG Network Operations Center, scientists who develop and conduct research, and member sites for enrollment of eligible subjects.
Deliverables
- Design and conduct clinical-translational studies for children with cancer
- Study novel therapeutic approaches (targeted small molecule drugs, immunotherapies, cellular therapies)
- Conduct clinical trials focused on improving quality of life for children with cancer and survivors
- Collection and annotation of biospecimens from children with cancer
- Support for the COG Network Operations Center
- Support for member sites to participate through enrollment of eligible subjects
