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Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)

US · MD National Institutes of Health (NIH) grant open #PAR-25-210
Response due Jun 02, 2027 · 00:00 UTC

Summary

The National Institutes of Health (NIH) is soliciting R33 grant applications focused on mechanistic research into precision probiotic therapies. The R33 mechanism supports the later, milestone-driven phase of high-risk, high-reward research. Clinical trials are optional under this funding opportunity. The opportunity is intended to advance scientific understanding of how probiotic interventions work at a mechanistic level, with a precision medicine orientation.

How they evaluate

Submission: Grants.gov federal grants portal

Risks & flags

  • Opportunity number PAR-25-210 is a Program Announcement with Review (PAR), which typically targets a specific research area and may favor established investigators already working in precision probiotics/microbiome fields
  • Multi-year open window (Oct 2024 – Jun 2027) is standard for NIH PARs but may concentrate awards among well-resourced research institutions

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541711
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Enhancing Mechanistic Research on Precisio…
Due Jun 02
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