Summary
This K23 award project aims to identify specific immune cells (T-betHi cells) and serum proteins (IFN-γ induced chemokines) that serve as indicators of disease severity, systemic organ burden, and pulmonary function in sarcoidosis patients.
Using high T-bet-expressing cells and Serum Chemokines as Indicators of Disease Severity in Sarcoidosis
US · IL
NIH
grant
awarded
#nih-5K23HL156000-05
What they want
The project involves studying T-betHi cells and IFN-γ induced chemokines (CXCL9, CXCL10, CXCL11) in well-phenotyped longitudinal sarcoidosis cohorts. Aim 1 will determine the relationship between IFN-γ production in T-betHi cells and their potential pathogenicity. Aims 2 and 3 will determine how T-betHi cells and these chemokines relate longitudinally to the number of affected organs and pulmonary function in two sarcoidosis cohorts. The awardee will also pursue a career development plan to expand skills in clinical research methods and T cell biology, including additional epidemiology and statistics coursework.
Deliverables
- Data to apply for R01 funding
Technical requirements
- Multi-parameter flow cytometry
- In vitro assays
- Clinical research methods
- T cell biology
- Epidemiology coursework
- Statistics coursework
Key personnel
- K23 awardee (researcher)
- Dr. Laura Koth (primary mentor)
- Dr. Woodruff (co-mentor)
- Dr. Allen (co-mentor)
