Summary
The project aims to develop synthetic protein mimics (PDMs) to inhibit protein-protein and protein-RNA interactions, specifically targeting intrinsically disordered proteins (IDPs) and double-stranded RNA (dsRNA) for therapeutic development.
Biomolecular Recognition with Synthetic Protein Mimics
US · IL
NIH
grant
open
#nih-5R35GM130333-08
What they want
The research will utilize a platform of Protein Domain Mimics (PDMs) to: 1) engage cellular Intrinsically Disordered Proteins (IDPs) with biomolecular receptors to inhibit IDP-mediated protein-protein interactions, and 2) develop encodable ligands for sequence-specific targeting of double-stranded RNA (dsRNA). The overall goal is to advance general approaches to inhibit protein-protein and protein-RNA complexes and establish PDMs as a new class of therapeutic constructs.
Deliverables
- advance general approaches to inhibit protein-protein and protein-RNA complexes
- establish PDMs as distinct constructs spanning the molecular size space between small molecules and proteins
