Summary
Project Summary The proposed translational studies will determine the cereroprotective efficacy of GSK2256294, an FDA- approved soluble epoxide hydrolase (sEH) inhibitor. Inhibition of sEH increases the endogenous levels of its substrate epoxyeicosatrienoates (EETs), which are endogenous brain lipid mediators with multiple mechanisms of action that are beneficial in stroke, including vasodilation, cytoprotection, anti-inflammation and suppression of platelet aggregation. Ample evidence from our group and others demonstrate that sEH inhibition and gene deletion reduce infarct size and improve f
