Summary
RECRUITMENT AND RETENTION FOR ALZHEIMER'S DISEASE DIVERSITY GENETIC COHORTS IN THE ADSP (READD-ADSP) - ABSTRACT THE GOAL OF THIS PROPOSAL IS TO CREATE A RESOURCE FOR STUDYING THE GENETIC ETIOLOGY OF ALZHEIMER DISEASE (AD) IN UNDERSTUDIED AND UNDERSERVED POPULATIONS. ALZHEIMER DISEASE (AD) IS THE LEADING CAUSE OF DEMENTIA IN THE ELDERLY AND OCCURS IN ALL ETHNIC AND RACIAL GROUPS. THE MAJORITY OF GENETIC STUDIES FOR AD HAVE BEEN PERFORMED IN NON-HISPANIC WHITES (NHW) OF EUROPEAN ANCESTRY. WHILE RECENT STUDIES HAVE BEGUN EXPANDING INTO OTHER POPULATIONS, THESE POPULATIONS ARE STILL UNDER-REPRESENTED IN AD GENOMICS, PARTICULARLY FOR CASES. A MAJOR BARRIER TO PARTICIPATION HAS BEEN A LACK OF COMMUNITY-SENSITIVE RECRUITMENT APPROACHES THAT OVERCOME HISTORICAL MISTRUST OF RESEARCH PARTICIPATION. GENETIC STUDIES ACROSS POPULATIONS, IN PARTICULAR AFRICAN AMERICANS (AA), HAVE SHOWN DIFFERENCES IN BOTH RISK EFFECT SIZE (E.G., APOE) AND RISK LOCI (E.G., ABCA7). FURTHER EVALUATION SUGGESTS THAT GEN
