Summary
SUMMARY Gaining a better understanding of aging biology is a pressing health and socioeconomic issue. In this regard, cellular senescence is a key, but poorly understood determinant of organismal aging. Senescence is a stress response program characterized by stable cell cycle arrest. Initially described as a tumor suppressor mechanism, it involves the interplay between the tumor suppressors p53 and RB leading to a transcriptional program of gene repression that silences proliferation associated genes. Beyond their arrest, senescent cells secrete the senescence associated secretory phenotype (
