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Forecast to Publish a Notice of Funding Opportunity for SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional)

US · IL National Institutes of Health (NIH) grant unknown #FOR-CA-25-086

Summary

The National Institutes of Health (NIH) is forecasting a Notice of Funding Opportunity (NOFO) for SBIR Phase IIB Bridge Awards aimed at accelerating the development of cancer-relevant technologies toward commercialization. This is a federal small business innovation research grant opportunity under the R44 activity code, with clinical trials optional. The opportunity is not yet open; it is a forecast notice indicating NIH intends to publish a formal funding announcement. Small businesses with cancer-related technologies progressing from Phase II SBIR toward commercial readiness are the intended applicant pool.

What they want

Award of SBIR Phase IIB Bridge grants (R44 activity code) to eligible small businesses to fund continued development of cancer-relevant technologies and accelerate their path to commercialization. Clinical trials are optional under this funding mechanism. The formal scope will be defined in the forthcoming Notice of Funding Opportunity (NOFO) published by NIH/NCI.
Technical requirements
  • Project must involve cancer-relevant technologies
  • Clinical trials are optional but permissible under the R44 mechanism
  • Work must align with SBIR commercialization objectives

How they evaluate

Submission: Grants.gov federal grants portal (formal submission process to be defined in forthcoming NOFO)

Eligibility & certifications

Must qualify as a small business concern under SBA SBIR eligibility rulesMust have completed a qualifying SBIR Phase II award to be eligible for Phase IIB Bridge funding

Risks & flags

  • This is only a forecast notice — the formal NOFO has not yet been published, so full requirements, deadlines, and evaluation criteria are unknown and subject to change.
  • No response due date, award ceiling, or detailed eligibility requirements are provided at this stage.

Market context

inferred from NAICS
Professional, Scientific & Technical Services
NAICS 541714
US market size
$2.0T
Typical award
$25K – $50M
Typical buyers
All federal civilianDoDStates
Commonly required
8(a)WOSBSDVOSBPE/PMP

Sector-level estimate — full code lookup not yet in catalog.

Forecast to Publish a Notice of Funding Op…
$unknown
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