Summary
This project aims to identify novel regulators of ER homeostasis in malignant plasma cells, specifically focusing on multiple myeloma, to develop new therapies by inducing cell death or preventing malignancy-fostering events.
Purinergic Receptors in Myeloma
US · IL
NIH
grant
open
#nih-1R01CA283844-01A1
What they want
The project hypothesizes that myeloma cells and their precursors avoid cell death by sensing extracellular ATP with purinergic receptors, and that eATP is produced locally by osteoblastic cells via Panx3. Inhibition of P2rX receptor signaling or Panx3 function is predicted to cause myeloma cell depletion. The research will leverage experimental systems, including a patient-derived xenograft model, to poison P2rX function in plasma cells, identify key ER regulatory nodes controlled by P2rX, and link P2rX function in MM cells to Panx3 regulation of the bone marrow plasma cell niche.
Deliverables
- Poison P2rX function in premalignant and malignant plasma cells
- Identify key ER regulatory nodes controlled by P2rX function
- Tie P2rX function in MM cells to Panx3 regulation of the BM PC niche
