The coordination of cell size control and cell cycle regulation at developmental extremes

Over the next five years, work in this R35 MIRA proposal will: 1) interrogate the molecular mechanisms by which maternally provided H3 contributes to cell size sensing at the mid-blastula transition (MBT); 2) understand how the nucleus to cytoplasm ratio (N/C ratio) affects nuclear and chromatin composition leading up to the MBT; and 3) extend the lab’s current models of cell size sensing to the growing egg chamber. The long-term goal is to understand cell size and cell cycle control in diverse tissue types and developmental timepoints.