Summary
Abstract/Summary PAD is characterized by impaired blood flow to the lower extremities, causing claudication and exercise intolerance. Up to now, assessment of PAD is mainly performed by determination of stenosis or occlusion in the large arteries and does not focus on microcirculation. Impaired arteriolar endothelial function, microvascular responsiveness to specific stimuli in patients with PAD may play a central role in disease development and progression. The impaired microvascular reactivity can be assessed by hyperemic response to contraction and cuff occlusion as well as in response to s
