Summary
This project investigates the role of synaptically released zinc in neuronal processing and brain function, aiming to understand its dynamics, regulation, and impact on neurological disorders.
The effects of synaptically released zinc on neuronal processing and brain function
US · IL
NIH
grant
awarded
#nih-2R35GM138023-06
What they want
The research focuses on understanding how brain-specific zinc transporter proteins control zinc release and clearance at synaptic terminals, how different brain cells utilize zinc during synaptic transmission, and how zinc regulates the activity and structure of individual synaptic connections. The five-year vision is to elucidate the dynamics of endogenous synaptic zinc in the brain, including its release, clearance, interaction with pre- and postsynaptic receptors, support of synaptic structure, and regulation by zinc transporter proteins.
